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Prostaglandin E2 (PGE2), as a key immunosuppressive mediator, can suppress the activity of CTLs [92], dendritic cells [91], and NK cells [93], thereby interfering with anti-cancer immune responses

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The meta-analytical study shows decreased abundance in the MDD patients when compared to controls in the bacterial families Veillonellaceae, Prevotellaceae, and Sutterellaceae, genera Coprococcus, Faecalibacterium, Ruminococcus, Bifidobacterium, Escherichia , and shows an increase in abundance in Actinomycetaceae family and Paraprevotella genus (Sanada et al., 2020)

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